Free NFL Picks Today: Arizona Cardinals vs San Francisco 49ers 11/21/22

Free NFL Picks Today: Arizona Cardinals vs San Francisco 49ers 11/21/22
Mon 21st November 2022

The Arizona Cardinals (4-6, 1-4 Home) take on the San Francisco 49ers (5-4, 2-3 Away) at Estadio Azteca on Monday. The 49ers are eight-point favorites, and the total is 43.5. San Francisco is coming off a 22-16 win over the Los Angeles Chargers at Levi’s Stadium last Sunday. Jimmy Garoppolo was 19 of 28 for 240 yards.

Elijah Mitchell ran 18 times for 89 yards. Brandon Aiyuk caught six passes for 84 yards. Arizona beat the Los Angeles Rams 27-17 at SoFi Stadium last Sunday. Colt McCoy threw for 238 yards and a touchdown. James Conner carried 21 times for 69 yards and two touchdowns. DeAndre Hopkins was targeted 14 times, hauling in 10 receptions for 98 yards.


The Cardinals won both games between the teams last season, including a 31-17 win in their last meeting in November. James Conner had three touchdowns (2 rush, 1 rec) for Arizona. Jimmy Garoppolo tossed two touchdowns for San Francisco.


The 49ers are averaging 22.0 points per game for the season, 18th in the NFL, and they are facing a Cardinals defense that has surrendered 25.8 PPG (30th). Meanwhile, Arizona has scored 23.0 points a game this season, 13th in the league, and San Francisco is allowing 18.1 PPG (4th).

The 49ers rank 13th in the league in passing yards per game (247.2) and 13th in rushing (123.7), while the Cardinals are 25th in passing yards allowed per game (261.9) and ninth against the run (110.5).Arizona is 16th in the league in passing yards per game (241.8) and 19th in rushing (113.1).

San Francisco’s defense could prove challenging on the ground, as the 49ers are 2nd in the league in rushing yards allowed per game (82.7). Against the pass, the 49ers are 11th (218.4).

Arizona ranks as the one of the lowest volume red zone offenses in the NFL, moving inside the 20-yard-line only 3.0 times per game (28th) and scoring a touchdown on 60% of those possessions (11th).


Through eight games, Jimmy Garoppolo has thrown for 11 touchdowns (4 INT) and 241.4 yards per game to lead San Francisco in passing. In four games away from home this season, he has seven TDs (3 INT) and an average of 248.8 yards passing. Jeff Wilson Jr. leads the team in rushing with an average of 58.5 yards a game over eight games. He has two touchdowns on the ground.

Brandon Aiyuk is the 49ers’ leading receiver with 63.0 yards a game and four TDs. Kyler Murray has 12 passing touchdowns (6 INT) with 240.9 yards per game through nine games to lead Arizona. Kyler Murray also leads the team in rushing with an average of 39.9 yards per game.

He has two touchdowns on the ground. Marquise Brown has been the primary target in the Cardinals’ passing game. He has three touchdowns and an 80.8 yard per game average through six appearances. Marquise Brown is averaging 10.7 targets per game (7.2 receptions).

SportsTips’ NFL Pick:

Over 43.5 (-110)

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*Odds correct at time of publication, courtesy of BetMGM.

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